الأمراض الوراثية

باحثون يفكون تشفير سلسلة من الجزيئات الضرورية لنمو وبقاء سرطان البنكرياس

الإعلامية حنان رجب

باحثون يفكون تشفير سلسلة من الجزيئات الضرورية لنمو وبقاء سرطان البنكرياس

ينجم سرطان البنكرياس القنوي الغدي (PDAC) في حوالي 95% من الحالات عن طفرة جين ورمي يدعى Kras تجعل من النمو الخلوي حدثية مستمرة، ولا يوجد علاج موافَق عليه حتى يومنا الحالي للأورام إيجابية طفرة Kras.

استطاع باحثون في تجربة على نموذج حيواني فك شيفرة سلسلة من الجزيئات الضرورية لنمو وبقيا PDAC واستهداف الجين الورمي YAP الضروري لتثبيط سرطان PDAC والذي يتفعل نتيجة طفرة Kras، كما اقترحت الدراسة أنّ استهداف كل من YAP و Sox2 -وهو جزيء يتفعل عند تثبيط YAP ويسمح للسرطان بالنجاة والنمو- يمكن أن يكون هاماً من أجل السيطرة طويلة الأمد على سرطان البنكرياس، وبالتالي اعطت مفاتيح يمكن استخدامها لحجب السبيل الاستقلابي الذي يزود الخلايا السرطانية بالوقود اللازم لاستمرارها، خاصة وأنّ مثبطات YAP طوِّرَت بالفعل وهي في طريقها للتجارب السريرية.

أجري البحث في: Georgetown University Medical Center
نشر في: Developmental Cell

لأننا نؤمن بالحياة.. نحن هنا

في شبكة أضواء الإخبارية، ندرك أن الخبر ليس مجرد حروف، بل هو نبضٌ وإنسان. من قلب التحدي في غزة، نسعى لصناعة غدٍ مشرق يمتد ضياؤه إلى العالم أجمع. رسالتنا هي بث الأمل ونشر الحقيقة، لنرسم معاً ملامح فجرٍ جديد يليق بطموحاتنا العظيمة.

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