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فسفرة العامل eLF2 يؤدي لإيقاف الترجمة في ظروف الإجهاد

الإعلامية حنان رجب

فسفرة العامل eLF2 يؤدي لإيقاف الترجمة في ظروف الإجهاد

تقوم الريبوزمات بعملية ترجمةmRNA لتحويله إلى بروتين بشكل مستمر، وفي حال تعرض الخلية لعوامل الإجهاد مثل الأشعة فوق البنفسجية تتخذ الخلية قرار إيقاف الترجمة بشكل مؤقت وذلك لتوفير الطاقة وتلافي حدوث أخطاء.

درس الباحثون الآلية الجزيئية التي يتم من خلالها إيقاف عملية الترجمة، وقد تبين أن فسفرة eLF2 (عامل يستهل عملية الترجمة ويحتاج لأداء عمله الارتباط مع عامل آخر eLF2B) تغير شكله الفراغي مما يمنع ارتباط عوامل أخرى معه، وبالتالي؛ يصبح eLF2 غير فعال، ويمنع عملية الترجمة. وقد جرى التوصل إلى هذه النتائج ودراسة بنية الجزيئات eIF2B و eLF2 المفسفر وغير المفسفر باستخدام المجهر الالكتروني فائق البرودة.

تضيف هذه الدراسة معلومات جديدة عن طريقة عمل الخلايا وآليات تنظيم العمليات المختلفة داخلها.

أجري البحث في: RIKEN Center for Biosystems Dynamics Research
نشر في: Science

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_WidgetInfo('HTML20', 'Postcs2', document.getElementById('HTML20'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML22', 'Postcs3', document.getElementById('HTML22'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML19', 'Postcs4', document.getElementById('HTML19'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML14', 'Postcs5', document.getElementById('HTML14'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML8', 'Postcs5', document.getElementById('HTML8'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML23', 'Postcs6', document.getElementById('HTML23'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML25', 'Postcs7', document.getElementById('HTML25'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML27', 'Postcs8', document.getElementById('HTML27'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML26', 'Postcs8', document.getElementById('HTML26'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML21', 'BotPostsc', document.getElementById('HTML21'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML6', 'BotPostsc', document.getElementById('HTML6'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML5', 'BotPostsc', document.getElementById('HTML5'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HeaderView', new _WidgetInfo('Header1', 'logo', document.getElementById('Header1'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_LinkListView', new _WidgetInfo('LinkList3', 'topsocialL', document.getElementById('LinkList3'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_LinkListView', new _WidgetInfo('LinkList001', 'menu', document.getElementById('LinkList001'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML100', 'Topa3lan-sc', document.getElementById('HTML100'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML101', 'Topa3lan-sc2', document.getElementById('HTML101'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_BlogSearchView', new _WidgetInfo('BlogSearch2', 'searchform', document.getElementById('BlogSearch2'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_LabelView', new _WidgetInfo('Label002', 'searchform', document.getElementById('Label002'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_BlogView', new _WidgetInfo('Blog1', 'Tempnec', document.getElementById('Blog1'), {'cmtInteractionsEnabled': false, 'lightboxEnabled': true, 'lightboxModuleUrl': 'https://www.blogger.com/static/v1/jsbin/3437970797-lbx__ar.js', 'lightboxCssUrl': 'https://www.blogger.com/static/v1/v-css/1964470060-lightbox_bundle_rtl.css'}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML11', 'sidepar', document.getElementById('HTML11'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_LinkListView', new _WidgetInfo('LinkList005', 'PostA3lan', document.getElementById('LinkList005'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML1', 'AddOns', document.getElementById('HTML1'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_HTMLView', new _WidgetInfo('HTML2', 'AddOns', document.getElementById('HTML2'), {}, 'displayModeFull')); _WidgetManager._RegisterWidget('_ContactFormView', new _WidgetInfo('ContactForm200', 'AddOns', document.getElementById('ContactForm200'), {'contactFormMessageSendingMsg': '\u062c\u0627\u0631\u064d \u0627\u0644\u0625\u0631\u0633\u0627\u0644...', 'contactFormMessageSentMsg': '\u062a\u0645 \u0625\u0631\u0633\u0627\u0644 \u0631\u0633\u0627\u0644\u062a\u0643.', 'contactFormMessageNotSentMsg': '\u062a\u0639\u0630\u0631 \u0625\u0631\u0633\u0627\u0644 \u0627\u0644\u0631\u0633\u0627\u0644\u0629\u060c \u064a\u0631\u062c\u0649 \u0627\u0644\u0645\u062d\u0627\u0648\u0644\u0629 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0641\u064a \u0648\u0642\u062a \u0644\u0627\u062d\u0642.', 'contactFormInvalidEmailMsg': '\u064a\u0644\u0632\u0645 \u0625\u062f\u062e\u0627\u0644 \u0639\u0646\u0648\u0627\u0646 \u0628\u0631\u064a\u062f \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0635\u0627\u0644\u062d.', 'contactFormEmptyMessageMsg': '\u0644\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u062d\u0642\u0644 \u0627\u0644\u0631\u0633\u0627\u0644\u0629 \u0641\u0627\u0631\u063a\u064b\u0627.', 'title': '\u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0627\u062a\u0635\u0627\u0644', 'blogId': '1057046826878960961', 'contactFormNameMsg': '\u0627\u0644\u0627\u0633\u0645', 'contactFormEmailMsg': '\u0628\u0631\u064a\u062f \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a', 'contactFormMessageMsg': '\u0631\u0633\u0627\u0644\u0629', 'contactFormSendMsg': '\u0625\u0631\u0633\u0627\u0644', 'contactFormToken': 'AOuZoY7wYAlFlrRvAQpxC64bVXBX0WEXdQ:1737174970193', 'submitUrl': 'https://www.blogger.com/contact-form.do'}, 'displayModeFull')); _WidgetManager._RegisterWidget('_TextListView', new _WidgetInfo('TextList88', 'sitteng-menu hide', document.getElementById('TextList88'), {}, 'displayModeFull'));